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7-14 mg/kg body weight: 4-8 capsules daily in 3-4 divided doses, 1 hour before or 2 hours after meals, with water. Milk products containing calcium, magnesium, aluminum (antacids) not to be taken with the capsules. Initially: 4-6 capsules to achieve dose of at least 10 mg/kg.
Prescribing Restrictions:  Medical Division Approval  

Second-line therapy in prostate carcinoma in advanced stages with hormone refractory tumors.
Known hypersensitivity to either estradiol or to nitrogen mustard derivatives, severe cardiovascular disease, complications related to fluid retention, severe hepatic disease.
Special Precautions:
Increased risk of thrombosis, fatal and non fatal myocardial infarction in men receiving estrogen for prostatic cancer, history of thrombophlebitis, thrombosis or thromboembolic disorders, cerebral vascular or coronary artery disease, diabetics, blood pressure to be monitored periodically. Conditions which might be influenced by fluid retention, metabolic bone diseases, renal insufficiency. Patients should be advised to use contraceptive measures.
Side Effects:
Gynecomastia, impotence, nausea/vomiting, fluid retention/edema, thromboembolism, ischemic heart disease, CHF., impairment of liver function.
Drug Interactions:
Tricyclic antidepressants, milk, milk products, aluminum, calcium, magnesium.