SOLUTION FOR INJECTION: 10 mg/ml. Dosage:
See prescribing information for full details. Prescribing Restrictions:
Initially: Advanced ovarian carcinoma in combination with other approved chemotherapy. Second treatment: Palliative treatment in advanced ovarian carcinoma recurring after prior chemotherapy, including those previously treated with cisplatin, metastatic small cell carcinoma of the lung. Contra-Indications:
Severe renal impairment, severe myelosuppression, history of severe allergic reactions to platinum-containing compounds or mannitol. Special Precautions:
Monitoring of renal function should be performed, determination of the hematological nadir by weekly blood counts, progressive and frequent development of anemia. Side Effects:
Myelosuppression and nephrotoxicity, liver function changes, allergic reactions. Drug Interactions:
Contact distributing company for full details.