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ACROSE
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 ACROSE
 
Package(a):
TABLETS: 30 x 50 mg.
Dosage(a):
Usual initial treatment: Week 1: 25 mg (½ of 50 mg tablet) at dinner. Week 2: 25 mg at breakfast and dinner. Weeks 3-4: 25 mg at breakfast, lunch, dinner. Week 5: Increase dose at dinner to 50 mg. Week 6: Also increase dose at breakfast to 50 mg. Weeks 7-8: 50 mg at breakfast, lunch and dinner. After 8 weeks, the patient's clinical response should be evaluated and dose adjusted accordingly. Week 9: Increase dose at dinner to 100 mg. Weeks 10-11: Also increase dose at breakfast to 100 mg. Week 12: 100 mg at breakfast, lunch and dinner. 
The tablet should be chewed or swallowed immediately at the beginning of the meal with the first mouthful. If a dose is forgotten, it should be taken at the next meal and not between meals.
Prescribing Restrictions:  None

Package(b):
TABLETS: 30 x 100 mg
Dosage(b):
Usual initial treatment: Week 1: 25 mg (½ of 50 mg tablet) at dinner. Week 2: 25 mg at breakfast and dinner. Weeks 3-4: 25 mg at breakfast, lunch, dinner. Week 5: Increase dose at dinner to 50 mg. Week 6: Also increase dose at breakfast to 50 mg. Weeks 7-8: 50 mg at breakfast, lunch and dinner. After 8 weeks, the patient's clinical response should be evaluated and dose adjusted accordingly. Week 9: Increase dose at dinner to 100 mg. Weeks 10-11: Also increase dose at breakfast to 100 mg. Week 12: 100 mg at breakfast, lunch and dinner. 
The tablet should be chewed or swallowed immediately at the beginning of the meal with the first mouthful. If a dose is forgotten, it should be taken at the next meal and not between meals.
Prescribing Restrictions:  None


Indications:
NIDDM in patients inadequately controlled by diet alone, or on diet and oral hypoglycemic agents.
Contra-Indications:
Hypersensitivity, pregnancy, lactation, chronic digestive system disorders, liver function disorders, renal insufficiency. See literature for full details.
Special Precautions:
When a high dosage is taken or when the medicine is taken concomitantly with other anti-diabetic medications, hypoglycemia may occur, in which case glucose/dextrose should be administered rather than sucrose. May cause elevation in liver enzymes. Therefore, liver enzymes should be monitored during the first 6-12 months of treatment. Safety and efficacy in children under 18 years have not been established.
Side Effects:
Increased flatulence, diarrhea, other abdominal aches. See literature for full details.
Drug Interactions:
Sulfonylureas, metformin, insulin, cholestyramine, digoxin, intestinal absorbents, and digestive enzyme preparations, activated charcoal preparations, neomycin.